PKRRATING NO FURTHER A MYSTERY

The interfacial residues are remarkably conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements exhibit that the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assist a design where activating RNA serves being a scaffold to bind a number of PKR monomers, expandi

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